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PENETRATION OF TOPICAL CORTICOSTEROIDS THROUGH HUMAN EPIDERMIS
Author(s) -
Osamura Hiromi
Publication year - 1982
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1982.tb02602.x
Subject(s) - penetration (warfare) , corticosteroid , clobetasol propionate , betamethasone , chemistry , human skin , blanching , hydrocortisone , stratum corneum , saline , endocrinology , pharmacology , medicine , biochemistry , biology , food science , pathology , operations research , engineering , genetics
The penetration of hydrocortisone, hydrocortisone 17‐butyrate 21‐propionate, betamethasone, betamethasone 17‐valerate, and clobetasol 17‐propionate through separated human epidermis was compared. The amount of each topical corticosteroid which was released on the skin and penetrated to saline was greater in ethanol solution than propylene glycol solution. The addition of water to the ethanol increased the release of some corticosteroids. The lipid solubility of each corticosteroid correlated well with skin penetration; however, the polarity of each corticosteroid was inversely proportional to skin penetration. The results of the blanching phenomenon caused by the application of these corticosteroids and of their skin penetration suggested to us that the local pharmacological activity of each topical corticosteroid, rather than their skin penetration, related well to their clinical effectiveness.