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PENICILLIN AND CEPHALOSPORIN—INDUCED RASH IN GUINEA PIGS
Author(s) -
Ikezawa Zenrō,
Kitamura Kazuko,
Murakami Junko,
Nagai Ryukichi,
Iwata Masayuki
Publication year - 1982
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1982.tb02598.x
Subject(s) - penicillin , rash , medicine , ampicillin , cephalosporin , guinea pig , immunology , antibiotics , antibody , cefazolin , microbiology and biotechnology , dermatology , biology
Guinea pigs primed for delayed type hypersensitivity (DH) to antibiotics such as penicillin G (PCG), carbenicillin (CBPC), sulbenicillin (SBPC), ampicillin (ABPC), cephalexin (CEX), cephalothin (CET) and cephazolin (CEZ) by immunization in mycobacterial adjuvant developed a generalized rash (GR) and flare‐up of previous test sites when challenged peritoneally with high doses of specific antigen. The GR was delayed in time, and histologically characterized by dilated and compacted small vessels and leucocytic infiltrations into the upper dermis. Animals immunized with CEX or CET developed a strong GR despite the absence of detectable antibodies. Hapten‐carrier specificity and cross‐reactivity in the GR system were essentially the same as those observed in skin testing of DH, but differed from those in the hemagglutination system. Accordingly, the GR shares many of the properties of DH skin test reactions: time course, histology, development despite an absence of detectable antibodies, carrier specificity, cross‐reactivity. This experimentally induced rash may be a useful model for delayed type, generalized, exanthematic drug eruptions in man.