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COMPARATIVE STUDY OF THE SENSITIVITY OF MOUSE DORSAL ROOT GANGLION AND CEREBELLUM TO HERPES SIMPLEX VIRUS IN VITRO
Author(s) -
Matsubara Motoo,
Ueda Keiichi,
Yasuno Hirokazu,
Maruo Michiru,
Yoshioka Akira
Publication year - 1982
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1982.tb01089.x
Subject(s) - dorsal root ganglion , herpes simplex virus , ganglion , biology , cerebellum , in vitro , virology , virus , antibody , tissue culture , simplexvirus , superior cervical ganglion , dorsum , latent virus , immunology , herpesviridae , anatomy , neuroscience , viral disease , biochemistry
To study the effect of Herpes simplex virus (HSV) on nervous tissue, we examined (1) the possibility of establishment of latent infection in vitro , (2) the replication of HSV in mouse dorsal root ganglion and cerebellar cultures and (3) the effect of anti‐HSV rabbit serum on the maintenance of both cultures. Although both cultures without antibody were finally destroyed after inoculation, replication of HSV in cerebellar cultures was much higher than in the ganglion in both medium and tissue (P<0.005). Infected cultures treated with anti‐HSV antibody (CF: ×128) could survive longer in nerve cells of ganglion than in those of cerebellum. These results suggest that the ganglion can resist HSV infection and this makes latent infection possible.