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ATYPICAL FIBROXANTHOMA OF THE SKIN A HISTOLOGICAL AND ELECTRON MICROSCOPIC STUDY
Author(s) -
Mihara Motoyuki,
Kanbe Naoto,
Shimao Shuhei,
Nakakuki Shigeya
Publication year - 1981
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1981.tb02592.x
Subject(s) - xanthoma , pathology , histiocyte , atypical fibroxanthoma , lesion , anatomy , electron microscope , giant cell , chemistry , biology , medicine , immunohistochemistry , physics , optics
A histological and electron microscopic case study of an atypical fibroxanthoma (AFX) of the skin was reported. The lesion developed on the left lower limb of a 23‐year‐old woman. Histologically, the lesion showed three zonal arrangements: spotty, small necrotic foci filled with erythrocytes in the central zone, pleomorphic and atypical cells in the intermediate zone; and interlacing collagenous bundles with storiform patterns in the peripheral zone. Tumor cells identified by electron microscopy were divided into undifferentiated mesenchymal, fibroblast‐like, histiocyte‐like and xanthoma cells. This suggested, histogenetically, that tumor cells of AFX of the skin may be fibrohistiocytic in nature. Furthermore, lipid droplets in xanthoma cells were classified into two types: smooth, oval or round shapes without a limiting membrane; irregular shapes with a limiting membrane.