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ADENOSINE DEAMINASE IN HUMAN SKIN
Author(s) -
Kim Young Pio,
Kahng Johng Bong,
Chon Joon Yul,
Ihm Chull Wan
Publication year - 1981
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1981.tb02567.x
Subject(s) - adenosine deaminase , dermis , epidermis (zoology) , deamination , adenosine , inosine , human skin , chemistry , biochemistry , biology , microbiology and biotechnology , enzyme , anatomy , genetics
Adenosine deaminase (adenosine aminohydrolase, ADA), which catalyzes the deamination of adenosine to yield inosine and ammonia, was assayed in human penile foreskin. The skin tissue was separated into two layers; epidermis and dermis. ADA was found to be present in both layers (epidermis, 0.24 Δ oD/mg protein; dermis, 0.19 Δ OD/mg protein) with slightly higher activity in the epidermis. As in earlier reports, it was found that ADA in the skin showed nearly even activity throughout the pH range of 5.0–8.0. Considering the significance of ADA in immunological function, the presence of ADA in the skin suggests that the tissue may participate in the immune function.