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IMMUNOFLUORESCENCE STUDY OF DRUG‐INDUCED LICHEN PLANUS‐LIKE LESIONS
Author(s) -
Watanabe Chiyeko,
Hayashi Tsutomu,
Kawada Akihiro
Publication year - 1981
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1981.tb02563.x
Subject(s) - immunofluorescence , pathology , antibody , direct fluorescent antibody , lichen , indirect immunofluorescence , medicine , dermatology , immunology , biology , botany
Using an immunofluorescence technique, we investigated lesions of drug‐induced lichen planus‐like lesions from patients. In addition, a comparative study of idiopathic lichen planus from thirteen patients was made. Deposits of fibrinogen along the epidermal basement zone, IgM, and less often IgA, IgG, C 1 q and C3 on the colloid bodies were found in drug‐induced lichen planus‐like lesions. Similar deposits of immunoglobulins and complements were noted in 2 of 3 lesions developed by successful provocation tests. Deposits of fibrinogen were also demonstrated in all 3 lesions. However, no circulating antibodies directed toward the epidermal basement zone or other skin components were detected. No elevation of circulating immune complex levels was noted. Immunofluorescence findings in drug‐induced lichen planus‐like lesions were essentially identical to those in idiopathic lichen planus. This indicates that both conditions share a common disease process.