Premium
GLYCOSAMINOGLYCAN IN THE SKIN AND URINE OF A HUNTER SYNDROME PATIENT WITH A SPECIFIC SKIN LESION
Author(s) -
Nakamura Toshitaka,
Nishida Kenju,
Matsuda Kazuko,
Kitano Yukio,
Sano Shigeharu,
Yutaka Tohru
Publication year - 1981
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1981.tb02559.x
Subject(s) - dermatan sulfate , glycosaminoglycan , urine , hyaluronic acid , heparan sulfate , chondroitin sulfate , chondroitin , skin lesion , lesion , chemistry , dermatology , medicine , pathology , biochemistry , anatomy
The glycosaminoglycan (GAG) contents of the cutaneous papules, the non‐eruptive skin, and the urine of a patient with Hunter syndrome were examined. Both skin samples contained hyaluronic acid (HA) and dermatan sulfate (DS) as major components and heparan sulfate (HS) and chondroitin sulfate (CS) as minor components. The HA content of the papules was greatly increased, while that of the non‐eruptive skin was normal. The amounts of DS and HS were increased in all three samples; the papules, non‐eruptive skin, and urine. HS from the patient's skin and urine had an electrophoretic mobility different from that of authentic HS. It seemed interesting from a pathogenetic viewpoint that the components of GAG in the cutaneous papules differed from those in the non‐eruptive skin and urine.