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ATYPICAL TYROSINASE POSITIVE ALBINOS
Author(s) -
Mizoguchi Masako,
Ishibashi Yasumasa,
HsinSu Yu,
Iijima Masafumi,
Hori Yoshiaki,
Kukita Atsushi
Publication year - 1981
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1981.tb02553.x
Subject(s) - albinism , tyrosinase , melanosome , melanin , tyrosine , incubation , homogeneous , biology , chemistry , microbiology and biotechnology , dermatology , biochemistry , medicine , enzyme , genetics , mathematics , combinatorics
Using light and electron microscopy, we studied five cases of tyrosinase positive albinism, with special reference to melanization of the hair‐bulbs before and after incubation with L‐tyrosine. Electron microscopic autoradiographs of the hair‐bulbs after incubation with 3 H‐L‐tyrosine were also investigated. As a result, it was found that three cases could be categorized as ordinary tyrosinase positive albinos, but the other two could not. It was concluded that tyrosinase positive albinism might not be a homogeneous disease, but a disease which can be divided into several subclasses.