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EXACERBATION OF PSORIASIS INDUCED BY INDOMETHACIN
Author(s) -
Katayama Hiroshi,
Kawada Akihiro
Publication year - 1981
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1981.tb02551.x
Subject(s) - exacerbation , psoriasis , pathogenesis , arachidonic acid , medicine , prostaglandin , pharmacology , mechanism (biology) , dermatology , chemistry , biochemistry , philosophy , epistemology , enzyme
In an attempt to clarify the role of prostaglandins in the pathogenesis of psoriasis, indomethacin, a potent inhibitor of prostaglandin synthesis, was administered orally to 6 psoriatic patients and topically to 5 patients. In all cases remarkable exacerbation of pre‐existing lesions was observed within 1 to 4 weeks. The possible mechanism of the clinical exacerbation was discussed with particular reference to arachidonic acid‐prostaglandin system.