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FIBROBLASTS AND IMMUNE COMPLEXES
Author(s) -
Ueki Hiroaki,
Nakaye Masako
Publication year - 1981
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1981.tb02534.x
Subject(s) - immune system , enzyme , acid phosphatase , in vitro , fibroblast , chemistry , biology , biochemistry , microbiology and biotechnology , immunology
Cultured human fibroblasts of 20 passages were incubated with in vitro ‐prepared complement‐fixed insoluble immune complexes for 4 or 24 hours. Three lysosomal enzymes, β ‐glucuronidase, N‐acetyl‐ β ‐glucosaminidase and acid phosphatase, were assayed in intra‐cellular and extra‐cellular samples. The three enzymes' activities were shown to increase remarkably in the intra‐cellular samples, but little in the extra‐cellular samples. These enzymes appeared to increase in or be released from the fibroblasts incubated with the immune complexes. Fibroblasts may play some role in eliminating immune complexes from the skin and in inducing inflammatory reactions.