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FIBROBLASTS AND IMMUNE COMPLEXES
Author(s) -
Nakaye Masako,
Ueki Hiroaki
Publication year - 1981
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1981.tb02533.x
Subject(s) - horseradish peroxidase , immune system , peroxidase , in vitro , connective tissue , chemistry , in vivo , microbiology and biotechnology , phagosome , fibroblast , biochemistry , biology , enzyme , immunology , phagocytosis , medicine , pathology
Cultured human fibroblasts were incubated with in vitro ‐prepared insoluble immune complexes consisting of horseradish‐peroxidase (HRP)‐anti HRP for 4, 24 or 48 hours. These incubated fibroblasts were then processed for electron microscopy. Peroxidase‐positive immune complexes were observed both on the surfaces and within the cytoplasms of the fibroblasts. However, the frequency of interiorized immune complexes or phagosomes was not high. It was speculated that, in connective tissue, fibroblasts can also adhere to and trap immune complexes in vivo , thus eliminating them from tissues under certain conditions.