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INFLUENCE OF HISTOCOMPATIBILITY ANTIGENS ON SKIN HOMOGRAFT SURVIVAL IN AN EXTENSIVELY BURNED PATIENT
Author(s) -
Higuchi Dousei,
Sei Yoshihiro,
Takiuchi Iwao
Publication year - 1981
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1981.tb02011.x
Subject(s) - abo blood group system , histocompatibility , antigen , histocompatibility testing , human leukocyte antigen , haplotype , medicine , immunology , graft rejection , hla a , transplantation , biology , surgery , genetics , allele , gene
Thirty‐eight donors were selected from 312 volunteers to be as nearly compatible as possible with the patient's HLA‐A and ‐B antigens. In addition to HLA‐A and ‐B, MLC test was performed between the patient and all but one of the 38 donors (Donor No. 35), and all 38 homografts were applied to the patient at once. The mean survival time of HLA‐A and ‐B‐identical grafts was better than two haplotype‐mismatched grafts. There were no clear differences between 0 and 1, or 1 and 2 haplotype‐mismatched grafts. No definite differences in the survival number at 21 days was observed between HLA‐A and ‐B‐identical grafts and 1 haplotype‐mismatched grafts. However, a significant difference was detected between (0+1) mismatched grafts and 2 mismatched grafts. We were not able to detect any effects of ABO blood antigens or sex on graft survival.