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HERPETIFORM PEMPHIGUS‐LIKE SKIN LESIONS INDUCED BY D‐PENICILLAMINE
Author(s) -
Morioka Shinji,
Ogawa Hideoki
Publication year - 1980
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1980.tb01996.x
Subject(s) - penicillamine , pemphigus , pemphigus vulgaris , medicine , rheumatoid arthritis , skin lesion , antibody , dermatology , titer , pathology , immunology
Herpetiform pemphigus‐like skin lesions appeared on a patient with rheumatoid arthritis who had been treated with D‐penicillamine. The pemphigus‐like antibodies reacted with normal human skin specimens at a titer of 1:5 serum dilution; however, the antibodies reacted more intensely with specimens of other's D‐penicillaminized skins and the patient's own skin. All of these skin lesions and abnormal antibodies disappeared after D‐penicillamine therapy was halted. In this patient, the pemphigus‐like antibodies might be induced by the drug with resulting skin lesions.