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BUSULFAN HYPERPIGMENTATION: LIGHT AND ELECTRON MICROSCOPIC STUDIES
Author(s) -
Adam B.A.,
Ismail Rokiah,
Sivanesan S.
Publication year - 1980
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1980.tb01993.x
Subject(s) - melanosome , hyperpigmentation , melanin , basal lamina , electron microscope , dermis , melanocyte , dermatology , ultrastructure , anatomy , chemistry , biology , medicine , biochemistry , melanoma , physics , genetics , optics
Skin with busulfan hyperpigmentation was studied using light and electron microscopy. There were both toxic effects on the melanocytes and stimulatory effects on the production of melanin. The mitochondria appeared damaged, and reduced in number. Cytoplasmic vacuoles, myelin figures and conglomerate masses of melanosomes were present. The melanosomes were normal in size but appeared increased. 'Ghost melanocytes' were found in the dermis. The basal lamina was damaged with evidence of duplication. Incontinence of melanin was seen. This hyperpigmentation may be similar to that in fixed drug eruption.