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ELECTRON MICROSCOPIC STUDIES OF POROKERATOSIS MIBELLI
Author(s) -
Sato Akihiko,
Masu Shinichi,
Seiji Makoto
Publication year - 1980
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1980.tb01979.x
Subject(s) - porokeratosis , epidermis (zoology) , lamella (surface anatomy) , lesion , keratin , corneocyte , pathology , biology , anatomy , stratum corneum , medicine
ABSTRACT Electron microscopic investigations of lesions from 5 cases of porokeratosis Mibelli clarified that the cornoid lamella was composed of two types of abnormal horny cells, the precursors of which were detected as dyskeratotic cells and autolytic cells in the epidermis directly beneath the cornoid lamella. Therefore, it was concluded that the cornoid lamella might be caused by a disturbance of keratinization of genetically fragile keratinocytes. On the other hand, some sort of repair mechanism might be present in the epidermis of the lesion by which degenerated epidermal cells (Civatte bodies) are transferred from the epidermis into the cutis. In the cutis of the lesion, Civatte bodies were found in one case and amyloid in three cases. However, neither the coexistence of both nor an intermediate form was detected. These findings strongly suggest a possible conversion of Civatte bodies into amyloid.