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CONTACT SENSITIVITY IN MICE INDUCED BY TOLYLENE DIISOCYANATE (TDI)
Author(s) -
Tanaka KenIchi
Publication year - 1980
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1980.tb01969.x
Subject(s) - swelling , immunology , hypersensitivity reaction , medicine , pathology
Contact sensitivity cannot be easily induced in mice by simple chemicals. The author has found that tolylene diisocyanate (TDI), which is widely used in industry, can produce a delayed type of hypersensitivity in mice. The delayed onset of the ear reaction and the histology of the ear swelling observed were characteristic of contact sensitivity. Adoptive transfer of contact sensitivity was possible in inbred mice. Since TDI is a causative agent of bronchial asthma, this discovery may be useful in clarifying the relationship between immediate and delayed types of hypersensitivity.