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ULTRASTRUCTURE OF SENILE KERATOSIS
Author(s) -
Kimura Shunji
Publication year - 1980
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1980.tb01966.x
Subject(s) - dermoepidermal junction , nucleolus , ultrastructure , endoplasmic reticulum , epidermis (zoology) , dermis , cytoplasm , biology , basal lamina , lamina densa , pathology , basal (medicine) , electron microscope , ichthyosis vulgaris , anatomy , microbiology and biotechnology , medicine , filaggrin , physics , atopic dermatitis , endocrinology , insulin , optics , immunology
Three cases of a hypertrophic type of senile keratosis were examined by an electron microscope. All three showed similar changes, although some variability from case to case was also observed. Lesional epidermis showed widened intercellular spaces with microvilli‐formation, a general increase in the bulk of the basal cells, a decrease in number of desmosomes, a decrease in the amount of tonofilaments, various degrees of aggregations of tonofibrils, binucleated keratinocytes, mitotic figures, prominent nucleoli, and an increase in number of nuclear bodies. In lesional dermoepidermal junctions, discontinuity of the basal lamina with cytoplasmic projections of the basal cells to the upper dermis was not infrequently observed. These changes are similar to those found in Bowen's disease, but are somewhat milder. In addition, in one case, keratinocytes of lesional epidermis showed lamellar structures closely associated with the rough endoplasmic reticulum. Significance of these structures is discussed.