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IMMUNE COMPLEX‐BEARING POLYMORPHONUCLEAR LEUKOCYTES IN PERIPHERAL BLOOD OF RABBITS WITH ACTIVE ARTHUS REACTIONS
Author(s) -
Ueki Hiroaki,
Nakaye Masako,
Masuda Toshiki
Publication year - 1980
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1980.tb01952.x
Subject(s) - arthus reaction , horseradish peroxidase , chemistry , immune system , antigen , immunology , antibody , immune complex , peripheral blood , antigen antibody complex , systemic circulation , peripheral , peroxidase , medicine , biochemistry , enzyme
Immune complex (I.C.)‐bearing polymorphonuclear leukocytes (PMN) were examined in the peripheral blood of rabbits in which active Arthus reactions had been induced by using horseradish peroxidase as an antigen. The I.C.‐bearing PMN's appeared in the circulation 1 or 2 hours after the induction of the Arthus reactions, decreased in number gradually and generally disappeared within 72 hours. Most of these I.Cs were formed in antibody‐excess. It may be speculated that I.C. is formed in the skin and transported into the systemic circulation or that free antigens escaping from the skin might bind directly with the corresponding antibody in the circulation and form I.Cs, which were subsequently phagocytosed by circulating PMN's. I.C.‐bearing PMN's in the peripheral blood may reflect in part immune deposits in the local tissues, which have occurred in the recent past (within 1 to 3 days). In conclusion, Arthus‐type reactions should be taken into account as an important source of circulating I.C. or I.C.‐bearing PMNs.