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PSEUDOPYOGENIC GRANULOMA
Author(s) -
Kimura Shunji
Publication year - 1980
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1980.tb01940.x
Subject(s) - extravasation , dermis , pathology , basal lamina , granuloma , endothelial stem cell , biology , medicine , anatomy , ultrastructure , in vitro , biochemistry
Papular lesions of pseudopyogenic granuloma were examined before and during treatment with systemic corticosteroid using both light and electron microscopy. Before treatment, these lesions showed a proliferation of vessels lined with plump endothelial cells and heavy lymphohistiocytic infiltrates with numerous eosinophils in the dermis. During treatment, flattened papules showed a dilatation of vessels lined with flattened endothelial cells, extravasation of red cells, discontinuity of endothelial basal lamina, and, ultimately, discontinuity of the endothelial cells themselves. Eosinophils were rarely found. From these findings, it can be said that the morphological effects of corticosteroid on microvasculature have in part been elucidated.