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DETECTION AND QUANTITATION OF 5‐S‐CYSTEINYLDOPA IN MELANOTIC AND AMELANOTIC MELANOMA IN COMPARISON WITH NONPIGMENT CELL TUMORS AND IT'S URINARY EXCRETION
Author(s) -
Mojamdar Manoj,
Ichihashi Masamitsu,
Mishima Yutaka
Publication year - 1979
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1979.tb01931.x
Subject(s) - melanoma , medicine , excretion , urine , urinary system , metastasis , amelanotic melanoma , metastatic melanoma , melanoma diagnosis , dermatology , pathology , cancer research , cancer
Recent investigations have shown that two major catechols, 5‐S‐cysteinyldopa and dopa are formed during melanogenesis. 5‐S‐cysteinyldopa has been shown to play a role in pheomelanogensis. The levels of 5‐S‐cysteinyldopa were estimated in tumors and urine of melanoma patients and were compared with those of non‐melanoma subjects. All melanotic melanomas, both primary and metastatic, contained substantial amounts of 5‐S‐cysteinyldopa. Urinary excretion of 5‐S‐cysteinyldopa increased with the duration of melanoma. The clinical and biological significance of 5‐S‐cysteinyldopa levels in estimating the extent of metastasis are discussed together with other clinical data from melanoma subjects.