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THE MAJOR HISTOCOMPATIBILITY COMPLEX IN PSORIASIS VULGARIS
Author(s) -
Ozawa Akira,
Matsuo Itsuro,
Niizuma Kan,
Ohkido Muneo,
Nose Yoshisuke,
Inouye Hiroo,
Tsuji Kimiyoshi
Publication year - 1979
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1979.tb01910.x
Subject(s) - psoriasis , linkage disequilibrium , typing , human leukocyte antigen , locus (genetics) , immunology , major histocompatibility complex , antigen , medicine , haplotype , allele , biology , genetics , gene
HLA‐C typing was performed on 40 unrelated Japanese patients with psoriasis vulgaris. The patient group consisted of 22 patients who had psoriatic HLA antigens i.e., B13 in seven cases, B17 in one case and B37 in 14 cases; and 18 patients who had none of these specific HLA antigens. HLA‐C typing was also performed on 40 unrelated healthy Japanese controls. Cw6 was found in 55.0% of the patients as compared with 5.0% of the healthy controls. All patients (21 cases) who had either B13 or B37 were positive for Cw6. Both controls who were positive for Cw6 also had B37. These results suggest the possibility of a linkage disequilibrium between Cw6 from locus C and B13 and B37 from locus B, and/or an association between Cw6 and susceptibility to psoriasis.