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ENZYMATIC STUDIES ON ADNEXAL TUMORS OF THE SKIN
Author(s) -
Aoyagi Takashi,
Kobayashi Hitoshi,
Kamigaki Katsuko,
Miura Yusho
Publication year - 1979
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1979.tb01909.x
Subject(s) - isocitrate dehydrogenase , enzyme , dehydrogenase , basal (medicine) , basal cell epithelioma , biology , cell , basal cell carcinoma , sebaceous gland , biochemistry , microbiology and biotechnology , basal cell , pathology , endocrinology , medicine , insulin
Sebaceous gland carcinoma (SGC), basal cell epithelioma with sebaceous cell differentiation (BCE+S) and basal cell epithelioma (BCE) were examined enzymatically, in order to elucidate the enzymatic characteristics of these tumors and the tumor cell origin of BCE+S. SGC demonstrated significantly higher enzyme activity of glucose‐6‐phosphate dehydrogenase (G‐6‐PDH), isocitrate dehydrogenase (ICDH) and α ‐glycerophosphate dehydrogenase (Gly‐PDH) than did BCE. BCE+S had an enzymatic pattern similar to BCE, except for Gly‐PDH which resembled SGC. The results obtained in this study indicated that BCE+S derived not from sebaceous gland cells but from primitive basal cells or epidermal cells which transformed into BCE and then partially differentiated toward sebaceous gland cells.