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THE MORPHOLOGY AND TIME COURSE OF IMMUNE COMPLEXES INJECTED INTO THE SKIN OF RABBITS
Author(s) -
Ueki Hiroaki,
Kubo Miyoko,
Nakaye Masako,
Aoshima Tadahiro,
Masuda Toshiki
Publication year - 1979
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1979.tb01896.x
Subject(s) - horseradish peroxidase , in vivo , erythema , edema , immune system , chemistry , necrosis , infiltration (hvac) , in vitro , peripheral blood mononuclear cell , peroxidase , pathology , immunology , biology , medicine , enzyme , biochemistry , materials science , microbiology and biotechnology , composite material
The morphology in in vitro prepared immune complexes (I.C.) using horseradish peroxidase as antigen and their behavior in the skin of rabbits were observed under the light microscope. Both in vitro and in vivo , solubilized I.C. were demonstrated as fine granular substances, while insoluble I.C. were shown to be lumpy or large granular aggregates. Solubilized I.C. injected into the skin disappeared quickly from the skin without being accompanied by the infiltration of polymorphonuclear leucocytes (PMN). Insoluble I.C. stayed in the skin longer and were phagocytosed by infiltrated mononuclear cells and PMN. Macroscopically, the former caused only slight skin edema, but the latter caused severe edema and erythema followed by induration, and also, occasionally, by necrosis.