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ANTI‐DNA ANTIBODIES OF VARIOUS SKIN DISEASES, ESPECIALLY OF SYSTEMIC LUPUS ERYTHEMATOSUS
Author(s) -
Idemori Masahiro,
Hanamiya Hideaki,
Yasaka Shoko,
Kudo Shoichiro,
Arao Tatsuyoshi
Publication year - 1979
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1979.tb01889.x
Subject(s) - titer , antibody , immunology , dna , medicine , antibody titer , lupus erythematosus , biology , genetics
Anti‐DNA antibodies of healthy controls and patients with various skin diseases, especially with SLE, were measured with a hemoagglutination test using erythrocytes labelled with DNA (DNA test manufactured by Fujizoki). The following conclusions were obtained. 1) Untreated SLE with acute symptoms presents a high anti‐DNA antibody titer in the DNA test. 2) The anti‐DNA antibody titer rises slightly later than do clinical symptoms. 3) If corticosteroids are given in sufficient doses at the beginning of SLE treatment, there is a possibility of the DNA test turning negative within two months. 4) The anti‐DNA antibody titer is kept at a dilution of 1:160 or less in well‐controlled SLE. 5) In addition to SLE, PSS also gives increased titers.