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GENERALIZED DISCOID LUPUS ERYTHEMATOSUS WITH BENIGN MONOCLONAL GAMMOPATHY
Author(s) -
Ueki Hiroaki
Publication year - 1979
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1979.tb01887.x
Subject(s) - medicine , cryoglobulins , multiple myeloma , discoid lupus erythematosus , macroglobulinemia , monoclonal , gammopathy , monoclonal gammopathy , paraproteinemias , lupus erythematosus , serum protein electrophoresis , precipitin , leukopenia , immunoelectrophoresis , anemia , bone marrow , immunology , pathology , monoclonal antibody , antibody , chemotherapy
This paper presents the case of a patient with generalized discoid lupus erythematosus. During the past 25 years the patient has developed moderate systemic symptoms including leukopenia, anemia, elevated erythrocyte sedimentation rate and decreased serum complement. In the last 7 years, the serum γ ‐globulin level has become conspicuously elevated, revealing a sharp monoclonal pattern. A M‐bow was detected in the IgG‐ and K‐chain precipitin arcs in immunoelectrophoresis. IgG type monoclonal gammopathy was confirmed, while the serum IgM level was decreased. No symptom suggesting the presence of multiple myeloma has ever been demonstrated by repeated bone X‐ray and the bone‐marrow examinations. The monoclonal gammopathy was well correlated with the intensity of cutaneous deteriolation and general symptoms.