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IMMUNOPATHOLOGICAL STUDIES ON PSORIASIS
Author(s) -
Kohda Mamoru,
Gotoh Masako,
Mimura Shigeru,
Namba Masako,
Nakagawa Shojiro,
Ueki Hiroaki
Publication year - 1979
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1979.tb01886.x
Subject(s) - fibrin , fibrinogen , staining , psoriasis , pathology , antibody , medicine , chemistry , dermatology , immunology , biochemistry
In vivo deposits of fibrin, fibrinogen, plasminogen, complements and immunoglobulins were observed using immunofluorescent (IF) staining of psoriatic lesions. Deposits of fibrin were seen in either the horny layer or the dermal papillae. A linear cytoplasmic appearance of fluorescence in the psoriatic scales was a common pattern of the staining. IF staining of the psoriatic horny layer for fibrinogen and plasminogen yielded essentially the same pattern as those of fibrin and IgG. These findings suggest that some fibrinolytic processes may be associated with an immune reaction in psoriatic skin, although they be secondary phenomena.