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HISTOGENESIS OF HYALINOSIS CUTIS ET MUCOSAE
Author(s) -
Ishibashi Akira
Publication year - 1978
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1978.tb01863.x
Subject(s) - basal lamina , pathology , elastin , chemistry , endoplasmic reticulum , pericyte , connective tissue , anatomy , fibrocyte , staining , tunica albuginea (penis) , elastic fiber , ultrastructure , biology , microbiology and biotechnology , endothelial stem cell , medicine , penis , biochemistry , in vitro
Light microscopically, reticulum fibers and argyrophilic materials were found by reticulum staining, and lipid droplets by Sudan III staining, around the blood vessels and in the interstices of the smooth muscle fibers of tunica dartos; toluidine blue staining of thick sections of Epon‐embedded tissue revealed poorly‐stained, glass‐like, amorphous hyalin with configuration of collagen fibers in the same areas and hyalinized muscle fibers in tunica dartos. Electron microscopy disclosed that multiplication of the basal lamina and its transition to the fibrogranular amorphous material, probably a hyalin substance, was seen around the true smooth muscle cells of tunica dartos and also around the blood vessels. In addition, dilated rough‐surfaced endoplasmic reticulums with fibrogranular content were often observed in the endothelial cells, pericytes, and smooth muscle cells, with Golgi apparatus in some parts. These findings suggest that hyalinosis cutis et mucosae is due to the accumulation and invasion of hyalin into the normal collagen fibers due to a genetic abnormality in the synthetic processes of smooth muscle cells, vascular endothelial cells, pericytes and some fibroblast‐like connective tissue cells. In my speculation, the hyalin substance in this disease may be normal collagen invaded by basal lamina glycoprotein, most probably involving type III and/or type IV collagen.