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THE “COLLOID BODY”—ITS NATURE AND PATHOGENESIS—
Author(s) -
Ishibashi Yasumasa,
Tsuru Noriko,
Kukita Atsushi
Publication year - 1978
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1978.tb01854.x
Subject(s) - epidermis (zoology) , colloid , ultrastructure , basal (medicine) , melanosome , stroma , electron microscope , chemistry , pathology , anatomy , biology , medicine , physics , biochemistry , optics , immunohistochemistry , insulin , melanin , endocrinology
The so‐called “colloid bodies” in lichen planus and lichen amyloidosus were observed ultrastructurally and compared with the changes of basal cells in “Futorafur dermatitis”, which occurs after long term administration of N 1 ‐(2′‐tetrahydrofuryl‐5‐fluorouracil). The “colloid bodies” were located in the intercellular spaces in the epidermis and freely in the stroma of the upper corium. They were mainly composed of fine filaments, and frequently contained some melanosomes, mitochondria and other vacuolated structures. These filaments had a constant width about 70 to 80 Å in diameter, which was much the same as those of tonofilaments in an adjacent keratinocytes. A number of desmosomes, to which these filaments convergently adhered, were occasionally observed in “colloid bodies”. This finding seems to support the theory that these filaments are themselves tonofilaments originating from keratinocytes, and they are fundamentally differentiated from other types of filaments in the dermo‐epidermal junction areas. The degenerative processes of basal cells in the epidermis in the lesions of “Futorafur dermatitis” seemed to be identical to those in formation of “colloid bodies” from keratinocytes in lichen planus.