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FIBRINOLYTIC THERAPY FOR PROGRESSIVE SYSTEMIC SCLEROSIS AND TISSUE FIBRINOLYTIC ACTIVITY IN AFFECTED SKIN
Author(s) -
Shigemi Fumio,
Fujita Tomomichi,
Ohsaki Masafumi,
Shiraishi Satoshi
Publication year - 1978
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1978.tb01059.x
Subject(s) - urokinase , progressive systemic sclerosis , fibrinolysis , medicine , fibrinolytic therapy , fibrinolytic agent , multiple sclerosis , immunology , tissue plasminogen activator , disease
In our present study, impairment of tissue fibrinolytic activity was observed in the affected skin of patients with progressive systemic sclerosis (PSS) by fibrinolytic autography. We treated PSS with a fibrinolytic agent, urokinase, based on the idea that the impairment of tissue fibrinolytic activity is implicated in the development of PSS. Two patients with PSS have responded favorably well to administration of Urokinase.