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EXPERIMENTAL HYPERKERATOSIS
Author(s) -
Ohkawara Akira,
Mizumoto Toshihiro,
Ohkuma Noritaka,
Honda Saho
Publication year - 1978
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1978.tb01042.x
Subject(s) - hyperkeratosis , dermatology , elderly people , medicine , epidermolytic hyperkeratosis , gerontology
The following conclusions will be drawn from the data obtained in this study. 1) Topical VA ointments which contain 5,000 IU and 10,000 IU VA respectively could not prevent n‐hexadecane‐induced epidermal proliferation and hyperkeratosis during the period studied. 2) After the epidermal hypertrophy and hyperkeratosis were established, continuous application of VA ointments of 5,000 IU and 10,000 IU resulted in even greater activity of the enzymes than those observed with the control (hydrophilic ointment alone). 3) Judging from the data obtained from the present study, VA ointment can be useful in the treatment of hyperkeratotic conditions characterized by the normal or decreased epidermal proliferation, because they promote the epidermal metabolic rate.