Premium
TISSUE FIBRINOLYTIC ACTIVITY OF ALLERGIC CONTACT DERMATITIS
Author(s) -
Shigemi Fumio,
Kitamura Yukikazu,
Ishimura Junya,
Takeda Katsuyuki
Publication year - 1977
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1977.tb01012.x
Subject(s) - allergic contact dermatitis , contact dermatitis , dermatology , medicine , allergy , immunology
One of our co‐workers was sensitized with a 1% DNCB solution in acetone. Biopsies were obtained from skin lesions 1, 2, 4, 8, 12, 24, 30, 36 and 48 hours after a challenge with 0.1% DNCB solution. In the upper dermis, a rapid decrease of tissue fibrinolytic activity was found which disappeared after 30 hours. In the lower dermis, biphasic changes were observed. Tissue fibrinolytic activity increased one hour and 12–36 hours after challenge, whereas at 48 hours, when erythema was most intensive, it decreased in comparison to the normal activity. Erythema and histological changes of the epidermis and the dermis appeared after approximately 12 hours. As for lymphocytes, T‐cells were seen at first. Furthermore, B‐cells were noted after approximately 30 hours when marked infiltration began to appear.