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SIGNIFICANCE OF IN VIVO‐BOUND IMMUNOGLOBULINS AND COMPLEMENT IN THE SKIN OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS
Author(s) -
Deng JauShyong,
Lin RueyYi,
Lü YauChin
Publication year - 1976
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1976.tb01849.x
Subject(s) - antibody , lupus nephritis , in vivo , medicine , human skin , immunology , pathology , basement membrane , nephritis , lupus erythematosus , complement (music) , dermatology , biology , phenotype , disease , biochemistry , genetics , microbiology and biotechnology , complementation , gene
A direct immunofluorescent test was used to demonstrate the in vivo deposits of immunoglobulin (Ig) and complement in the skin of 30 patients with systemic lupus erythematosus (SLE). These deposits were demonstrated in all skin lesions and in 70% of apparently normal skin of patients with lupus nephritis. On the contrary, they were seldom found in seemingly normal skin of patients without nephritis, though they could be seen in skin lesions. There was significant difference between these two groups and as well as an intimate relation of the deposits to clinical severity. The fixed Ig and/or complement could be found in a band arrangement in the basement membrane zone (BMZ) area, nuclear areas of epidermal and/or dermal cells or both BMZ area and nuclear areas.