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TRIPLE FUNGAL INFECTION—CHRONIC MUCOCUTANEOUS CANDIDIASIS, EXOPHYTIC DERMATOPHYTOSIS AND CRYPTOCOCCAL MENINGITIS: A NEW AND UNUSUAL COMBINATION—
Author(s) -
Matsumoto Tadahiko
Publication year - 1976
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1976.tb01834.x
Subject(s) - chronic mucocutaneous candidiasis , cryptococcal meningitis , medicine , dermatology , mucocutaneous zone , cryptococcosis , immunology , pathology , human immunodeficiency virus (hiv) , disease , viral disease
The clinical and immunological studies of an unusual case of chronic mucocutaneous candidiasis (CMCC) are reported. An 18‐year‐old male with life‐long CMCC was superinfected by a dermatophyte showing exophytic clinical features in his childhood. In addition he has suffered from fatal cryptococcal meningitis since the age of 18. The combination of three fungi, i.e., Candida albicans, Trichophyton mentagrophytes and Cryptococcus neoformans , has not been found in an examination of the literature. The author's hypothesis, “immune deviation theory” in the pathogenesis of CMCC, is presented in detail. The possible role of hypovitaminosis A and disorder of iron metabolism in CMCC and treatment of CMCC are reviewed briefly.