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ULTRASTRUCTURE OF THE MICROVASCULATURE IN SKIN AFFECTED BY SYSTEMIC SCLERODERMA
Author(s) -
Saito Yoshio,
Ishikawa Hidekazu
Publication year - 1976
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1976.tb01832.x
Subject(s) - ruthenium red , dermis , ultrastructure , basal lamina , collagen fibril , pathology , lamina densa , anatomy , electron microscope , fibril , connective tissue , chemistry , microcirculation , vesicle , anchoring fibrils , lumen (anatomy) , papillary dermis , biology , medicine , microbiology and biotechnology , calcium , biochemistry , physics , organic chemistry , membrane , optics
ABSTRACT The microvasculature of the upper dermis in cases of systemic scleroderma was examined with an electron microscope. Microvessels in clinically uninvolved skin areas showed nearly normal structure. On the other hand, in moderately involved skin, enlargement of the vascular lumen, endothelial swelling, increase in the pinocytotic vesicle and microvilli and reduplication of the basal lamina were observed. Along with these, Ruthenium red‐positive granules, microfibrils and fine collagen fibrils were perivasculary increased. Markedly involved skin revealed a degenerative change in the endothelial cells with interendothelial gap; in the perivascular region the number of microfibrils and Ruthenium red‐positive granules decreased, and were replaced by increased collagen fibrils.