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CELL‐MEDIATED IMMUNITY IN MYCOSIS FUNGOIDES *
Author(s) -
Kinoshita Masako,
Kawada Akihiro
Publication year - 1976
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1976.tb00978.x
Subject(s) - mycosis fungoides , medicine , sensitization , lymphocyte , immunity , transformation (genetics) , immunology , dermatology , pathology , immune system , chemistry , lymphoma , biochemistry , gene
The immunologic status of patients with mycosis fungoides in various stages was studied by testing skin reaction to PPD, by sensitization with topical application of 2,4 dinitrochlorbenzene, and by in vitro lymphocyte transformation test with PHA. Skin reaction to PPD was depressed in 7 of 8 patients and sensitization to dinitrochlorbenzene was impaired in 6 of 8 patients. In PHA‐induced lymphocyte transformation, when autologous serum was added to the culture medium, the transformation rate was below normal in 7 of 8 patients. When autologous serum was replaced by normal serum, the rate was usally improved and, in 3 patients, recovered to normal range. However, in the remaining 4 patients of whom 3 were at the infiltrative plaque stage, the rate was still below normal (21.5–36.6%). It is suggested that at least in 3 patients there was a serum factor which lymphocyte transformation by PHA. In 2 patients with poikiloderma atrophicans vasculare and parapsoriasis en plaques, no influence of serum was noted.