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LYMPHOCYTE TRANSFORMATION USING STREPTOCOCCAL ANTIGENS AND SERUM ANTISTREPTOKINASE TITERS IN BEHÇET DISEASE
Author(s) -
Yamada Mizuho,
Fujimoto Fumio,
Uragami Kozo,
Yanase Keiko
Publication year - 1975
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1975.tb00959.x
Subject(s) - streptococcus pyogenes , pathogenesis , behcet's disease , immunology , antigen , medicine , streptococcus , titer , antistreptolysin , disease , immune system , biology , antibody , pathology , staphylococcus aureus , bacteria , genetics
The etiology of Behçet disease is still unknown. Some investigators have suggested that streptococci may play a role in the pathogenesis of Behçet disease. High antistreptolysin‐O (ASLO) and antistreptokinase (ASK) titers were not detected in out‐patients with Behçet disease. In our studies a considerably high percentage of blast cells was observed in lymphocyte transformation tests using streptolysin‐O antigen, streptokinase‐streptodornase (Varidase), Streptococcus nonhemolyticus, Streptococcus viridans , and Streptococcus pyogenes as the antigens in the cases of Behçet disease. Serum ASLO and ASK titers did not indicate significant relations among these results. The percentage of blast cells in the studies was not high in any case of Behçet disease, but it seemed that a cell‐mediated immune reaction to streptococci might play a role in the pathogenesis of the disease.