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AN AUTORADIOGRAPHIC STUDY ON THE PERCUTANEOUS ABSORPTION OF A TOPICAL CORTICOSTEROID, WITH REFERENCE TO THE EFFECTS OF OCCLUSIVE TREATMENT AND STRIPPING
Author(s) -
Takeda Yushi
Publication year - 1975
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1975.tb00951.x
Subject(s) - stripping (fiber) , absorption (acoustics) , percutaneous , occlusion , corticosteroid , chemistry , occlusive dressing , biomedical engineering , nuclear medicine , medicine , surgery , materials science , pathology , composite material , alternative medicine
The effects of occlusive treatment and stripping on the percutaneous absorption of a topical corticosteroid (17‐α‐desoxymethasone) were studied on human skin by means of a direct mounting method of autoradiography. A greater density of developed silver grains was found in the epithelium of occluded skin than in non‐occluded skin. The influence of occlusion on trans‐appendageal absorption was demonstrated by a greater density of grains in the cutaneous appendages of occluded skin as compared to non‐occluded skin. Further, a step‐wise increase in grain deposition was seen in specimens stripped repeatedly with adhesive tape. A partial removal of keratin by stripping was detected histologically, this suggests that the entire horny layer acts as a limiter of percutaneous absorption.