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EXPERIMENTAL CONTACT DERMATITIS IN MICE
Author(s) -
Kawamura Yukio,
Sonobe Katsuya,
Shimizu Masayuki,
Hamaguchi Tsuguo
Publication year - 1974
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1974.tb01068.x
Subject(s) - spongiosis , contact dermatitis , mitosis , sensitization , epidermis (zoology) , hairless , immunology , chemistry , biology , dermatology , microbiology and biotechnology , medicine , anatomy , allergy , biochemistry
Dermatitis due to contact with DNCB was studied in mice. The reaction was shown by pathomorphological and autoradiographic studies to be an increase in epidermal mitotic activity. Sensitization of thymectomized mice, NZB mice, and passive transfer with peritoneal exudate cells demonstrated that this increase in epidermal mitotic activity is dependent upon cell‐mediated or delayed hypersensitivity. Although the induction of epidermal changes of eczematous contact dermatitis in mice has been considered difficult, by challenging acanthotic mouse epidermis we have been able to produce such changes as lymphocytic basal spongiosis. These results indicate that mice as well as guinea pigs are useful in experimental contact dermatitis.