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COLLAGEN‐LIKE PROTEIN IN SERUM OF PATIENTS WITH CONNECTIVE TISSUE DISORDERS
Author(s) -
Kishihara Yukiko,
Sasaki Soichiro,
Sano Shigeharu
Publication year - 1974
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1974.tb00922.x
Subject(s) - dermatomyositis , connective tissue , medicine , systemic scleroderma , pseudoxanthoma elasticum , scleroderma (fungus) , connective tissue disease , pyoderma gangrenosum , pathology , lupus erythematosus , systemic disease , dermatology , immunology , immunopathology , autoimmune disease , antibody , disease , inoculation
Collagen‐like protein (CLP) was demonstrated in the serum of normal human individuals and of patients with connective tissue disorders. The average amount of CLP in normals was 9.1 ± 0.2 μg/ml, whereas in systemic scleroderma, circumscribed scleroderma, and systemic lupus erythematosus the amounts were significantly lower. Serum CLP levels were also found to be decreased in pseudoxanthoma elasticum, striae atrophicae, and impetigo herpetiformis, but variable in dermatomyositis, and within normal limits in pyoderma gangrenosum. There seemed to be a relationship between the behavior of collagen‐like protein and the severity of clinical manifestations in systemic scleroderma and systemic lupus erythematosus.