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Changes in serum concentrations of tumor necrosis factor α and adhesion molecules in normal pregnant women and those with pregnancy‐induced hypertension
Author(s) -
Matsubara Keiichi,
Abe Emiko,
Ochi Hiroshi,
Kusanagi Yasuki,
Ito Masaharu
Publication year - 2003
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1341-8076.2003.00141.x
Subject(s) - medicine , cell adhesion molecule , tumor necrosis factor alpha , pregnancy , e selectin , gestation , adhesion , endocrinology , intercellular adhesion molecule 1 , cell adhesion , selectin , immunology , chemistry , biology , genetics , organic chemistry
Abstract Aim: To study whether serum tumor necrosis factor α gene (TNFα) and adhesion molecule levels are indicators of the onset of pregnancy‐induced hypertension (PIH), we compared levels of these molecules between normal pregnant women and PIH patients from the first to the third trimester. Methods: We serially measured serum concentrations of TNFα, soluble intercellular adhesion molecule‐1 (sICAM‐1), soluble E‐selectin (sE‐selectin), soluble vascular cell adhesion molecule‐1 (sVCAM‐1) and soluble P‐selectin (sP‐selectin) using enzyme immunoassay kits in 10 normal pregnant women and 10 pregnant women who developed PIH late in gestation. Results: Serum TNFα, sICAM‐1 and sE‐selectin levels in PIH affected women were significantly higher from the first trimester compared with those in normal pregnancy. sVCAM‐1 and sP‐selectin levels were not significantly changed. Conclusion: Serum TNFα, sE‐selectin and sICAM‐1 levels might be effective indicators of the onset of PIH.