Premium
Chemical Processing of CaHPO 4 ·2H 2 O:
Author(s) -
Tas A. Cuneyt,
Bhaduri Sarit B.
Publication year - 2004
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/j.1151-2916.2004.tb07490.x
Subject(s) - brushite , apatite , aqueous solution , calcination , anhydrous , nuclear chemistry , simulated body fluid , phosphate , calcium , chemistry , sodium , hydroxymethyl , inorganic chemistry , pyrophosphate , mineralogy , materials science , organic chemistry , enzyme , catalysis
The aim of this paper is to develop a robust chemical process to synthesize Na‐ and K‐doped brushite (DCPD: dicalcium phosphate dihydrate, CaHPO 4 ·2H 2 O), a potential starting material for bone substitutes. The powders were synthesized by using sodium phosphate and potassium phosphate and aqueous solutions containing calcium chloride at room temperature, followed by drying at 37°C. DCPD powders thus formed were found to contain 460 ppm K and 945 ppm Na. On calcination in air, these powders readily transformed into monetite (DCPA: dicalcium phosphate anhydrous, CaHPO 4 ) first, and then into Ca 2 P 2 O 7 (calcium pyrophosphate). Na‐ and K‐doped DCPD powders were shown to completely transform, in less than 1 week, into poorly crystalline carbonated apatite on immersion in an acellular simulated/synthetic body fluid (SBF) solution at 37°C. The Tris (i.e., tris(hydroxymethyl)aminomethane) buffered SBF solution used in this study had a carbonate ion concentration of 27 m M equal to that of human plasma. DCPD powders of this study displayed a notable apatite‐inducing ability. This finding suggests the use of these DCPD powders as the starting materials for potential bone substitutes, which can be easily manufactured in aqueous solutions friendly to living tissues, at temperatures between room temperature and 37°C.