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Curcumin and its derivatives prevent hepatocyte lipid peroxidation in Anabas testudineus
Author(s) -
Manju M.,
Sherin T. G.,
Rajeesha K. N.,
Sreejith P.,
Rajasekharan K. N.,
Oommen O. V.
Publication year - 2008
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/j.1095-8649.2008.02044.x
Subject(s) - anabas testudineus , lipid peroxidation , antioxidant , biology , curcumin , hepatocyte , biochemistry , reactive oxygen species , incubation , pharmacology , toxicology , in vitro , fishery , fish <actinopterygii> , perch
The present study evaluated the effect of five different curcuminoids, CURI, CURII, CURIII, a mixture of the three and a synthetic, curcumin–boron–oxalic acid complex, on Anabas testudineus hepatocyte lipid peroxidation after 30–60 min of incubation. The results showed that curcumin had a protective role as a strong antioxidant in teleosts. All the curcuminoids decreased the peroxidation products formed, with or without stimulating the antioxidant enzyme pathway. This suggests a direct reactive oxygen‐species scavenging ability of curcuminoids. Their antioxidant effects appear to be time and dose‐dependent.