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Insulin‐like growth factor‐binding protein‐1: an evolutionarily conserved fine tuner of insulin‐like growth factor action under catabolic and stressful conditions
Author(s) -
Kajimura S.,
Duan C.
Publication year - 2007
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/j.1095-8649.2007.01606.x
Subject(s) - biology , growth factor , catabolism , microbiology and biotechnology , insulin , insulin like growth factor , insulin like growth factor binding protein , insulin receptor , receptor , biochemistry , endocrinology , metabolism , insulin resistance
The insulin‐like growth factor‐binding proteins (IGFBPs) are evolutionarily conserved components of the insulin‐like growth factor (IGF) system. The six forms of IGFBPs (IGFBP‐1–6) bind the IGF ligands (IGF‐1 and ‐2) with high affinity and regulate the IGFs available to their receptors, therefore providing additional flexibilities in regulating IGF signalling. IGFBP‐1, the first identified member of the IGFBP family is highly inducible under a variety of catabolic conditions, such as food deprivation, malnutrition, stress, injury and hypoxia. Recent in vivo studies have indicated that the induced IGFBP‐1 serves as a molecular switch by restricting IGF signalling and diverts the limited energy resources away from growth and development towards those metabolic processes essential for survival. This article reviews the recent understandings of the molecular basis of IGFBP‐1 regulation and its biological functions, as revealed through research in mammalian and fish models.