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Abnormal dorsal light response in teleost fish after intraocular injection of 6‐hydroxydopamine
Author(s) -
McCormack C. A.,
McDonnell M. T.
Publication year - 1994
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/j.1095-8649.1994.tb01333.x
Subject(s) - hydroxydopamine , dopamine , biology , dorsum , retinal , fish <actinopterygii> , oxidopamine , anatomy , endocrinology , dopaminergic , biochemistry , fishery , substantia nigra
Following unilateral intraocular injection with 6‐hydroxydopamine to the right eye, Midas cichlids displayed an acute abnormal dorsal light response, in favour of the right eye. This condition was reversed immediately by dopamine or dopamine receptor agonists delivered by intraocular injection but this recovery was not sustained, Retinal dopamine production reappeared gradually from day 30 post‐6‐hydroxydopamine treatment, and coincided with the fish beginning to adopt a normal dorsal light reaction. Dopamine production recovered completely at day 45 post‐6‐hydroxydopamine injection and coincided with complete recovery of the normal dorsal light reaction. These observations suggest a role for intraocular dopamine in maintenance of the visual part of the normal dorsal light reaction.