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In vitro effects of zinc on lymphoid cells of the carp, Cyprinus carpio L.
Author(s) -
Cenini P.,
Turner R. J.
Publication year - 1983
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/j.1095-8649.1983.tb02937.x
Subject(s) - cyprinus , carp , biology , common carp , spleen , kidney , in vitro , medicine , zinc , endocrinology , immunology , fish <actinopterygii> , fishery , biochemistry , chemistry , organic chemistry
Cells from the spleen, anterior kidney, middle kidney, thymus and peripheral blood of common carp were tested in culture at 22°C. Unlike mammals, zinc was not found to be a mitogen but to have a suppressive effect. This was usually detectable at very low concentrations (10 −7 M), although the degree of suppression varied depending on the organ investigated. Direct toxic effects of the metal were only observed at high concentrations (0·5 × 10 −3 m or greater). The use of carp serum supplement rather than foetal calf serum was important in demonstrating these effects.