Premium
The immune response of the brown trout, Salmo trutta , L. to MS2 bacteriophage: immunogen concentration and adjuvants
Author(s) -
O'Neill J. G.
Publication year - 1979
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/j.1095-8649.1979.tb03586.x
Subject(s) - salmo , brown trout , immunogen , biology , bacteriophage , adjuvant , immune system , antibody , trout , neutralization , antibody response , inoculation , humoral immunity , virology , microbiology and biotechnology , immunology , monoclonal antibody , fish <actinopterygii> , fishery , biochemistry , escherichia coli , gene
The humoral antibody response to single intraperitoneal inoculations of MS2 bacteriophage was followed in Salmo trutta using a 50% bacteriophage neutralisation litre ( sd 50 ) method. Immune memory was observed with enhancement of both the time and level of antibody production, though an initial suppression was observed 7 days after secondary inoculation. Antibody titres were related to MS2 concentration, and adjuvants were found to enhance the response. An increased enhancement of antibody production by Freund's complete adjuvant over that of incomplete adjuvant was observed.