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A study of the conversion of cholesterol to bile acids by the use of a fistulated bile duct
Author(s) -
Kallner Anders
Publication year - 1977
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/j.1095-8649.1977.tb04127.x
Subject(s) - biology , cholic acid , cholesterol , metabolite , bile duct , medicine , bile acid , metabolism , common bile duct , biochemistry
A method for the surgical preparation of a bile fistula in the sculpin Myoxocephalus quadricornis is presented. This model was used in demonstrating the conversion of 14 C‐cholesterol into bile acids. The main acid metabolite was cholic acid and the presence of dihydroxy bile acids was also demonstrated. The amount of labelled compounds which was recovered in the bile was small both in case of parenteral administration to fistulated sculpins and after peroral administration to intact animals. This may be attributable to slow metabolism at the low ambient temperature these animals require to survive.