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The primary immune response of brown trout ( Salmo trutta ) to injection with cellular antigens
Author(s) -
Ingram George A.,
Alexander John B.
Publication year - 1977
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/j.1095-8649.1977.tb04042.x
Subject(s) - biology , antibody , hemolysin , antigen , immune system , brown trout , immunology , hemolysis , salmo , microbiology and biotechnology , typhoid fever , salmonella typhi , fish <actinopterygii> , biochemistry , escherichia coli , fishery , virulence , gene
The primary immune response of brown trout ( Salmo trutta L.) was studied after injections of two cellular antigens– Salmonella typhi H, flagellar antigen d, and human group ‘O’Rh+ red blood cells. Both intraperitoneal and intramuscular injections were employed. Agglutinins and complement–fixing antibodies were produced to S. typhi and haem–agglutinins to human ‘O’ red blood cells. Maximum titres to S. typhi were reached after 49 days in the case of both agglutinins and complement‐fixing antibody. Haem‐agglutinins reached a maximum value of 1 : 512 between 35 and 42 days. Haemagglutinins to human ‘O’ red blood cells were detected as early as 7 days after injection. Antibodies against S. typhi were found after 14 days. Natural haemolysins were present against horse, sheep and human groups ‘A’, ‘B’ and ‘AB’ but not with group ‘O’. No natural haemagglutinins were present to the six types of red blood cells tested. No precipitins were detected to either S. typhi or human ‘O’ red blood cells by immunodiffusion.