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Ultrastructural changes in the hepatocytes of green sunfish, Lepomis cyanellus Rafinesque, exposed to solutions of sodium arsenate
Author(s) -
Sorensen Elsie M. B.
Publication year - 1976
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/j.1095-8649.1976.tb03947.x
Subject(s) - arsenic , ultrastructure , biology , arsenate , endoplasmic reticulum , lepomis , sodium arsenate , electron microscope , arsenic poisoning , hepatocyte , sodium , fish <actinopterygii> , biochemistry , anatomy , chemistry , fishery , physics , organic chemistry , optics , in vitro
The rate and level of arsenic accumulation in the liver of green sunfish is greater than that in the other organs examined. The level to which arsenic is concentrated is positively associated with the concentration of arsenic, in solution in the immediate environment of a fish, the duration of exposure to arsenic, and water temperature, Since it was found that accumulation causes histopathological changes, a study was made to examine the appearance of and rate of change in hepatocyte ultrastructure morphology following exposure to arsenic concentrations of 0, 30, or 60 ppm and after exposure times of one, two, or three weeks at 20°C. As arsenic concentration and exposure time increased, electron dense particles were observed, and the numbers of intranuclear and cytoplasmic electron dense particles and aberrant mitochondria increased. Also, lysosomes and smooth endoplasmic reticulum increased in number, while the number of myelin figures decreased.