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The Swiss/ICR (Ha) albino mouse as an experimental host for infectious pancreatic necrosis virus of trout
Author(s) -
Angiolelli R. F.,
Rio G. J.
Publication year - 1971
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/j.1095-8649.1971.tb03656.x
Subject(s) - infectious pancreatic necrosis virus , biology , necrosis , pancreas , inoculation , trout , virus , virology , host (biology) , vacuole , microbiology and biotechnology , cytoplasm , immunology , endocrinology , fish <actinopterygii> , ecology , fishery , biochemistry , genetics
Intracranial inoculation of infectious pancreatic necrosis virus (IPNV), a pathogen of several species of trout, produced pancreatic necrosis in suckling Swiss albino mice. Peri‐nuclear halos, cytoplasmic vacuoles, and necrosis were found in histologic sections of pancreas taken from mice killed 21 days post‐inoculation. Virus was recovered from the pancreas of mice killed as early as 10 days post‐inoculation. Rivers' postulates were fulfilled. Virus recovered from the infected mouse pancreas was neutralized by IPNV specific antiserum. The significance of the mouse as an experimental host is discussed.